Gold(I)-catalyzed intramolecular acetylenic Schmidt reaction.

نویسندگان

  • David J Gorin
  • Nicole R Davis
  • F Dean Toste
چکیده

Substituted pyrroles were prepared by a gold(I)-catalyzed acetylenic Schmidt reaction of homopropargyl azides. The reaction allows for regiospecific substitution at each position of the pyrrole ring under mild conditions. A mechanism in which azides serve as nucleophiles toward gold(I)-activated alkynes with subsequent gold(I)-aided expulsion of dinitrogen is proposed.

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عنوان ژورنال:
  • Journal of the American Chemical Society

دوره 127 32  شماره 

صفحات  -

تاریخ انتشار 2005